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Edward Middleton Manigault (1887–1922) was a Canadian-born American Modernist painter.

Manigault moved to New York City in 1905 and enrolled in classes at the New York School of Art where he studied under Robert Henri and Kenneth Hayes Miller, alongside classmates such as Edward Hopper, George Bellows, and Rockwell Kent. By 1909, he had moved away from Realism and had begun producing paintings in a Post-Impressionism style. In that year he first exhibited his work in New York, and in 1910 he participated in the Exhibition of Independent Artists, organized by Henri. In the spring of 1912, he traveled through England and France. In 1913, he his work was included in the Armory Show. In 1914, he staged a critically acclaimed one-man show at the Charles Daniel Gallery. His art was purchased by such notable collectors as J. Paul Getty and Arthur Jerome Eddy.

Later the same year, Manigault travelled without his wife to San Francisco and began working in a Cubist style, but, displeased with the results of this departure from his typical work, he destroyed nearly two hundred of his own paintings. At around this time in his life, Manigault had begun to practice fasting, in the hopes that starvation and meditation would allow him “to approach the spiritual plane and see colors not perceptible to the physical eye.”

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